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High-Tech Smell Sensors Aim to Sniff Out Disease, Explosives—and Even Moods

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We live in a world of odors—chemical signals that contain valuable data about our health, the environment and even personal choices like which foods, perfumes and beverages we enjoy. Despite decades of research and development, however, this aromatic information has remained mostly untapped.

But now scientists and entrepreneurs are redoubling their efforts to recreate the sense of smell in compact devices that detect and analyze odors similar to the way cameras now recognize our faces and microphones our words. In pursuit of these high-tech devices–which could use odors to detect disease like cancer or Covid-19, locate hidden explosives or decipher our moods and behaviors—some companies are leveraging advances in synthetic biology and genetic engineering. Others are harnessing advances in artificial intelligence.

utely a growing field,” says Andreas Mershin, an odor-sensor researcher at the Massachusetts Institute of Technology. “We’re recognizing that there’s a whole world of molecules we’re blind to.” He calls the field an “unexplored goldmine.”

The quest to build better olfactory sensors is a challenging one because odors are made up of many different chemicals and because animals’ olfactory receptors—specialized cells in the nose that recognize odor molecules—are remarkably diverse. Humans have three types of receptors for color vision, for instance, but hundreds of different olfactory receptors.

Among the most futuristic devices are those that incorporate living cells engineered to react to specific odor components. Koniku Inc., a startup in San Rafael, Calif., is now using bioengineered nerve cells as the basis for sensors capable of recognizing the subtle odors of explosives. The cells contain proteins designed to detect so-called volatile organic compounds, carbon-containing substances that seep into the air from a range of sources, including food, paints, beverages, bodies and unexploded bombs.

“We design smell cyborgs,” says Osh Agabi, founder and chief executive of the firm. He says the firm is working with Airbus Americas to develop sensors for use at airports to detect packages and luggage containing explosives. The goal is not to replace bomb-sniffing dogs and other security measures now in use but to augment them, according to Bruce Coole, head of aviation-security programs at Airbus Americas.

In recent tests at San Francisco International Airport, a prototype of Koniku’s bomb-sniffing device identified pieces of planted luggage known to contain explosives with an accuracy of 97%, according to Dr. Agabi. In separate tests, Koniku’s sensors matched trained dogs’ ability to detect explosives, he says, adding that the company is also developing sensors for use in healthcare and other industries.

“When you look at the scale of how many compounds or how many smells are impacting human life that are yet to be cataloged, we have barely scratched the surface,” Dr. Agabi says.

Aromyx Corp., a startup in Mountain View, Calif., is also using cells to create odor sensors. But rather than selling devices, it offers food and wine producers a lab-based service to help them better understand the specific odor molecules that drive consumer preferences. Company workers pair consumer-survey data on people’s likes and dislikes with how Aromyx’s bioengineered odor-detecting cells react to certain odor molecules to come up with preference profiles.

“The value is not in the sensor, but in the data,” says Josh Silverman, Aromyx’s chief executive.

MIT’s Dr. Mershin is focusing on medical applications of olfaction technology. Inspired by dogs that have demonstrated an ability to sniff out malignancies in humans, he’s working on an artificial-intelligence odor-detection system to detect prostate cancer.

In 2021, Dr. Mershin’s team published results showing that their system matched trained dogs’ ability to detect prostate cancer in the urine of patients with the disease. Since then the team has increased the software’s accuracy to more than 90%, Dr. Mershin says, adding that the system is more reliable than the well-known prostate-specific antigen (PSA) blood test, which can lead to false-positive diagnoses. Only 25% of men who undergo a prostate biopsy following a suspicious PSA finding are later found to have cancer,

Olfaction experts warn that a series of scientific and technical challenges must be overcome before high-tech odor detectors are ready for broad penetration into the marketplace. For systems that use living cells, it will be important to monitor how often devices need to be replaced and how accuracy stacks up over long time frames, they say.

“The idea is great. It’s the implementation that’s the problem,” says Nathan Lewis, a chemist and olfaction-sensor developer at the California Institute of Technology.

Scientists and data rights experts say the emergence of sophisticated molecular surveillance—for example. turning cell phones into what some experts call “smell phones” capable of spotting medical conditions— raises thorny questions of privacy. After all, odors our bodies constantly emit contain clues about our health and personal choices, including the products we use and the foods we eat as well as our drinking and smoking habits and more. The collection and analysis of human olfactory data could affect some insurance coverage, for example, as well as employment, according to legal experts.

“We’re not prepared for the implications,” says David Carroll, an associate professor of media design at the Parsons School of Design and a data-rights activist. “It’s going to bring up deep and profound ethical quandaries.”

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The Best Recommended Resorts in Nusa Dua Bali

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The Best Recommended Resorts in Nusa Dua Bali

Nusa Dua is one of Bali’s areas built specifically for tourism in the 1970s. Since then, many luxury hotels and resorts were built everywhere in the Nusa Dua area. For those who want an exciting vacation with family or friends, there are many choices for the bali resort nusa dua .

These accommodations have luxurious facilities ranging from spas, private swimming pools, restaurants, and many more. All resorts in Nusa Dua also have sparkling white sand and calm waves as their view. What are the recommendations for the best resorts in Nusa Dua?

Best Resort Recommendations in Nusa Dua Bali

1. Laguna Resort & Spa

Staying at Laguna Resort & Spa will make you feel very comfortable. When entering the resort, you will be greeted with the sound of a gong and dancers in traditional costumes showing off their artistic talents. Laguna Resort & Spa also provides spacious rooms with large beds and luxurious bathrooms. 

Each room has a tropical garden interspersed with a lagoon pool. This resort also has gym facilities, a spa, and a sumptuous breakfast. There is also a beach bar if you want a cocktail. If you want to stay in a place that offers luxurious facilities and emphasizes local culture, pay a visit to Laguna Resort & Spa. The lodging at this resort is also not so expensive compared to other luxury hotels in Nusa Dua.

2. Resort St. Regis Bali

Located on the sand of Nusa Dua beach, St Regis is the next choice of resort for accommodation options. This resort has a traditional Balinese concept with olive green furnishings. Interestingly, you can swim in a vast lagoon from Resort St. Regis Bali, the size is three times the size of the Olympic swimming pool. 

Furthermore, this resort is also equipped with a thalassotherapy spa. Resort St. Regis Bali also provides a ‘Children’s Learning Center’ facility so parents who bring their children can leave them there. The Children’s Learning Center offers a curriculum to stimulate and entertain children while their parents enjoy the holidays.

3. Hilton Bali Resort

Hilton Bali Resort is perched on a cliff overlooking the beautiful Indian Ocean. You can see Nusa Lembongan clearly from this resort because of its location on a cliff. Hilton Bali Resort is facilitated with a family swimming pool with water slides, an outdoor playground that will make the kids happy, a spa, and a kids club. There are also gazebos and loungers on the private beach. At sunset, there is an observation tower that you and your family can visit to see the fantastic sunset views.

You can visit the lodging recommendations above for those traveling with their family and looking for the best resorts in Nusa Dua, Bali. All of them have extraordinary views with complete and luxurious facilities!

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4 Important Tips for Having a Vacation Abroad

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4 Important Tips for Having a Vacation Abroad

Are you planning to go abroad but still don’t know what to prepare? People dream of going abroad, especially to countries like America and Europe. If this is your first time going abroad, you should check the following tips!

Prepare All Important Documents

The first thing you need to do is prepare important documents. For example, passports, ID cards, visas, and international driving licenses if you are going to drive abroad. Make sure you know whether the country you are going to visit is visa-free or not. For Southeast Asian countries, the Maldives and Turkey are visa-free, so you only have to have a passport. But a visa is still needed if you want to go to South Korea, Europe, or America. Make sure to scan your document and save it in the cloud like Google Drive or iCloud. Oh, yes, remember to check your vaccination status. Because every country needs your health information.

Make Itineraries

Itinerary is important for those who want to travel abroad. The reason is holidays abroad cost a lot of money, so when you can, take advantage of it with a well-planned schedule. Research in detail the tourist destinations you want to visit. For example, what is unique in it, ticket prices, transportation to get there, to the distance from the inn you’re staying. Remember to include places to eat that you want to try. Make sure the place to eat is according to your preferences, such as halal or free of certain food allergies.

Book Tickets in Advance

When you know how long you will be on vacation with the itinerary that has been prepared, it’s time to book plane tickets and lodging. Find cheap tickets by:

  1. Using promos and discounts on travel agent applications.
  2. Comparing which price is lower and what kind of facilities you will get.
  3. Choosing accommodation that fits your budget but is still comfortable.

Oh yes, also remember to check how the pandemic situation is in the country you are going to visit. Do you have to quarantine or not? Because it will affect your itinerary and accommodation. Due to the pandemic conditions that have not fully recovered, check whether there is still Indonesia quarantine after returning from vacation.

Exchange Money and Check Your ATM Cards

Exchange your currency into the destination country’s currency, for example, yen, euros, dollars, won, and others. But remember, don’t carry too much cash because it’s also prone to theft, besides being wasteful. For the rest, you can do cashless transactions. Check your bank’s ATM card to see if it has Visa, MasterCard, or Cirrus logos. This row of stamps indicates that your bank is working with banks abroad. Or you can also use a credit card to make your transaction easier.

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Down 43%, Is This Tech Stock Worth Buying Right Now?

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Down 43%, Is This Tech Stock Worth Buying Right Now?

Skyworks Solutions (NASDAQ: SWKS) announced its fiscal 2022 fourth-quarter results (for the three months ended September 30) on November 3, and the supplier Apple’s stock price has risen 11% since then.

Skyworks beat expectations and showed solid growth at a time when smartphone sales were declining, but forecasts show the chipmaker is about to hit a bump. With that said, let’s take a closer look at the latest results from the chipmaker. Let’s take a closer look at whether the stock can sustain new momentum after losing 43% of its value in 2022.

Skyworks solutions deliver reliable results for non-mobile businesses
Skyworks’ fourth-quarter revenue increased 7% year-over-year to a record $1.4 billion. The company also reported non-GAAP (adjusted) earnings of $3.02 per share, up 15% year-over-year. Skyworks easily justified analyst estimates of $2.91 per share. For the year, the company’s revenue increased 7% to $5.5 billion and earnings rose similarly to $11.24 per share.

The strong growth of chipmakers in the fourth quarter was the result of successful diversification into new markets such as Internet of Things (IoT) and automotive, as well as relationships with major smartphone original equipment manufacturers (OEMs). Yes, it helped make up for it. Weakness in the smartphone market. space. However, it was the non-mobile business that put a lot of effort into Skyworks last quarter.
As CFO Chris Sennesael noted in the report, the company generated $500 million in revenue from broad market segments (counting chip sales for non-mobile applications like IoT), up 30% from the previous year. Last earnings conference call. Broad market companies contributed 36% of Skyworks’ revenue last quarter, up from 29% in the same period last year.

It’s also worth noting that Skyworks earned $2 billion in revenue from this segment for the entire fiscal year. That’s almost 43% more than the $1.4 billion in revenue last fiscal year. The good news is that the company’s business in a wide range of markets can maintain its momentum. This is because, as Skyworks showed in its earnings report, it is attracting new customers in high-growth niches like IoT.

“In IoT, we continue to win new customers and expand our content. We have partnered with Vodafone to launch the UK’s first WiFi 6E platform. We have launched a solution for Fi 6 hotspots.”

Skyworks also enables the deployment of O-RAN (Open Radio Access Network) and delivers record quarterly results in the high-growth automotive business niche. For example, the O-RAN market is expected to grow at an annual rate of 42% until 2030. Meanwhile, according to Mordor Intelligence, the demand for connected cars will grow by 19% per year until 2027.

These catalysts explain why Skyworks expects its broad commercial segment of the market “to be a major driver in FY23 and beyond.”

The mobile business was not in its best last quarter
Skyworks’ mobile business generated approximately $907 million in revenue last quarter (this is total revenue minus $500 million from the broader market business). By comparison, 71% of Skyworks’ $1.31 billion in revenue last year came from its mobile business, worth nearly $931 million.

Thus, the company’s mobile business, which generates most of its revenue, declined year-over-year in the most recent quarter. This is not surprising given that smartphone sales have been declining for the past five quarters. Skyworks considers Apple its biggest client, with the smartphone giant generating 58% of its revenue last year.

Last quarter, Apple shipped 48.5 million smartphones, 6.4% more than last year. However, the overall smartphone market was down 9% year-over-year. And now things could get even worse for Skyworks.

All of this explains why Skyworks management is targeting a sharp drop in sales and profits. The chipmaker expects revenue of $1.3 billion to $1.35 billion and adjusted earnings of $2.59 per share in the first quarter of fiscal 2023. These numbers show double-digit declines in both revenue and earnings compared to the last year.

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